"Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience" | EMH Swiss Medical Publishers Ltd |
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At the end of NREM sleep, the VLPO area neurons directly inhibit the REM-off cells, which completely disinhibits the REM-on cholinergic neurons and initiates REM sleep | Biological rhythms, sleep, and hypnosis |
"Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C".
7"Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C" | "Narcolepsy and automatic behavior: A case report" |
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Orexin neurons are significantly decreased in number in narcoleptic patients | "The origin of REM sleep: A hypothesis" |
Thus, the shift in the evening bedtime across cohorts accounted for the substantial decrease in sleep duration in younger children between the 1970s and the 1990s.